LIFE Fivefold improvement of sensor chemistry sensitivity

14 Jan 2025 07:00 CET

Bergen, Norway, 14 January 2025: Today, Lifecare ASA (LIFE), a clinical stage
medical sensor company developing the next generation Continuous Glucose
Monitor (CGM), can announce significant improvement in glucose sensor
sensitivity based on a new generation of Lifecare's proprietary chemistry.

The sensor sensitivity defines the potential to detect small changes of
glucose levels and is an important performance parameter for CGM. Lifecare has
managed to improve the sensitivity up to five-fold in laboratory experiments,
compared to sensitivity achieved with our original chemistry.

This significant improvement in sensitivity is expected to beneficially impact
Lifecare's sensor in several aspects, whereof the most important is the
potential for even more precise measurements providing increased accuracy of
glucose monitoring. The accuracy of CGM's is commonly referred to based on
Mean Absolute Relative Difference (MARD), where a MARD lower than 10%
indicates clinically acceptable accuracy.

In Q2 2023, data from Lifecare's Clinical Development Study LFC-SEN-001
confirmed that our CGM system had achieved a MARD of 9,7%. The fivefold
improvement of chemistry sensitivity in vitro leads to an expectation that the
MARD can be significantly improved with the potential of being superior to
MARD of available CGMs in the market.

In a product perspective the most prominent benefit of enhanced sensor
sensitivity is improvement of the sensor signal-to-noise ratio. This leads to
improved data readings and enhanced sensor performance, as well as simplifying
of algorithms and data processing efficiency.

Consequently, the enhancement of sensitivity is expected to improve the
precision and quality in glucose monitoring ensuring better outcomes for
end-users, while simplification of sensor and software can be expected to
reduce the manufacturing complexity yet enhance sensor reliability.

- All in all, the new chemistry marks a significant step forward for our
sensor technology. It is expected to improve both performance and production,
ensuring an enhanced user experience through increased accuracy and reduced
complexity, says CEO Joacim Holter.

This announcement aligns with the operational review in the Q3 2024 report,
which emphasized ongoing efforts to refine and strengthen processes.

- We are actively identifying opportunities to optimize product and production
tolerances to meet the highest quality standards. This focused approach will
drive substantial advancements in production consistency and product quality,
reinforcing our commitment to delivering a high-quality implant to the market,
adds Holter.

Introduction of this new generation of chemistry is not expected to affect the
progress and production timeline of the Lifecare CGM sensor but will provide
an improved product for the commercial market. Subject to validation we are
assessing the potential for filing a new patent to protect this innovation.

Lifecare remains dedicated to pushing the boundaries of CGM technology,
ensuring both exceptional product performance and user satisfaction.

About us
Lifecare ASA is a clinical stage medical sensor company developing technology
for sensing and monitoring of various body analytes. Lifecare's main focus is
to bring the next generation of Continuous Glucose Monitoring ("CGM") systems
to market. Lifecare enables osmotic pressure as sensing principle, combined
with the ability to manipulate Nano-granular Tunnelling Resistive sensors
("NTR") on the sensor body for read-out of pressure variations. Lifecare's
sensor technology is referred to as "Sencell" and is suitable for identifying
and monitoring the occurrence of a wide range of analytes and molecules in the
human body and in pets.

Contacts
For further information, please contact:

Joacim Holter, CEO, joacim.holter@lifecare.no, +47 40 05 90 40

Renete Kaarvik, CFO, renete.kaarvik@lifecare.no, +47 94 83 82 42

More information:
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