ArcticZymes' M-SAN HQ Sets New Standard for Measles Virus Purification with Unmatched DNA Clearance and High Recovery Rates

21 Nov 2024 12:05 CET

Tromsø, Norway - November 21, 2024 - ArcticZymes Technologies ASA (OSE: AZT), is
proud to highlight the exceptional performance of our M-SAN HQ nuclease in the
purification of recombinant measles viruses (MV), as detailed in a recent
publication in the Journal of Chromatography A. The study demonstrates how
integrating M-SAN HQ nuclease with heparin affinity chromatography streamlines
MV purification, achieving unmatched levels of both purity and yield.

Innovative Approach to MV Purification

The study, titled "Highly Pure Measles Virus Generated by Combination of Salt
-Active Nuclease Treatment and Heparin Affinity Chromatography," by Mayer et al.
addresses the challenges of purifying fragile, enveloped viruses like MV.
Traditional methods often involve multiple steps, risking viral loss and reduced
yields. By combining M-SAN HQ nuclease treatment with heparin affinity
chromatography, researchers achieved a simplified workflow that enhances both
purity and recovery rates.

Key Findings

· Enhanced Purity: The integrated approach effectively removes host-cell DNA
and proteins, resulting in highly pure MV preparations.
· Increased Yield: The streamlined process minimizes viral loss, leading to
higher recovery rates compared to conventional methods.
· Workflow Simplification: The combination reduces the number of purification
steps, decreasing processing time and complexity.

Why This Matters

In the development of vaccines, gene therapies, and oncolytic treatments,
manufacturers know that ensuring product purity is critical to meeting stringent
regulatory standards and safeguarding patient safety. Host cell DNA
contamination, a common challenge in viral vector production, must be reduced to
levels below the FDA threshold of 10 ng/dose to ensure compliance and
therapeutic efficacy. Traditional nucleases, included in the study, struggle to
consistently meet these standards without adding complexity and cost, e.g.
additional filtration, to the purification process.

M-SAN HQ nuclease addresses this challenge head-on, achieving DNA clearance far
below the 10 ng/dose while also maintaining exceptionally high recovery of virus
particles. This unique combination of performance and efficiency enables
manufacturers to streamline their workflows, reduce the need for additional
purification steps, and improve overall production yields.

For patients, this means faster access to safe, effective therapies; for
manufacturers, it translates into lower costs, greater reliability, and
confidence in meeting regulatory expectations. M-SAN HQ is paving the way for
more robust, scalable, and accessible solutions in biopharmaceutical production.

"M-SAN HQ keeps us a step ahead by delivering the ideal balance of high purity
and high yield, giving CDMOs, pharma and biotech companies the efficiency and
reliability they need to succeed." said ArcticZymes CEO, Michael Akoh.

Ask any questions regarding the publication in this custom GPT and learn more
about the new publication
here (https://www.arcticzymes.com/blogs/revolutionizing-measles-virus
-purification-insights-new-study-journal-of-chromatography).

ArcticZymes Technologies ASA
CEO, Michael B. Akoh | Tel: +46 (0) 70 262 37 15
CFO, Børge Sørvoll | Tel: +47 95 29 01 87
ir@arcticzymes.com

About ArcticZymes Technologies ASA

ArcticZymes Technologies ASA (OSE: AZT) is a global leader in enzyme
technologies, developing innovative solutions that enhance the efficiency of
bioprocessing and support the creation of cutting-edge therapeutics. From
optimizing biomanufacturing workflows to ensuring regulatory compliance,
ArcticZymes enzymes, including SAN HQ and M-SAN HQ, are transforming the
landscape of gene therapy and viral vector production.

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632825_PR_M_SAN_Sets_New_Standard_for_Measels_Virus_Purification.pdf