Ultimovacs Receives Intention to Grant Notice on European Patent on UV1 Cancer Vaccine-Checkpoint Inhibitor Combinations

13 Apr 2023 11:31 CEST

* Protects UV1 vaccine-checkpoint inhibitor combinations in cancer until at
least 2037
* Covers UV1 combined with CTLA-4, PD-1 or PD-L1 checkpoint inhibitors
* Notice of intention to grant received in Europe. Corresponding patent
granted in the US, additional applications pending

Oslo, 13 April 2023: Ultimovacs ASA ("Ultimovacs") (OSE ULTI), a clinical stage
leader in immune stimulatory vaccines for cancer, received a Notice of Intention
to Grant from the European Patent Office (EPO) concerning its European Patent
application 17729078.0 on the use of vaccine-checkpoint inhibitor combinations
to treat cancer.

Subject to grant formalities including translations and fee disbursement, the
European patent will issue with a patent term to June 2037. When granted, the
European patent and its counterpart in the US add substantially to the strong
intellectual property base Ultimovacs is building around UV1 combination
therapies. Supplementary Patent Certificates around UV1-combination therapies
have the potential to further extend protection beyond 2037.

The patent is the European counterpart of the US patent No. 11419927 which was
granted in August 2022. The Company has similar patent applications pending in
other territories worldwide, including Japan, Canada and Australia. They cover
synergistic cancer treatments that include the UV1 peptide vaccine in
combination with an anti-CTLA-4, anti-PD-1 or anti-PD-L1 antibody checkpoint
inhibitor. The primary patents of many of the current CTLA-4 and PD-1/PD-L1
checkpoint inhibitors face expiry over the course of the next several years.

"We are pleased that the novelty and utility of Ultimovacs' combination
immunotherapies have been acknowledged by both the United States Patent and
Trademark Office and now by the European Patent Office," said Carlos de Sousa,
Chief Executive Officer of Ultimovacs. "Ultimovacs continues to build
substantial intellectual property around UV1-checkpoint inhibitor combinations
while exploring the clinical value of the combinations across many cancers
through an extensive Phase II clinical trial program."

==ENDS==

About Ultimovacs
Ultimovacs is a clinical-stage biotechnology leader developing novel
immunotherapeutic cancer vaccines to treat a broad range of cancer types.
Ultimovacs' lead universal cancer vaccine candidate, UV1, targets human
telomerase (hTERT), present in 85-90% of cancers in all stages of tumor growth.
By directing the immune system to hTERT antigens, UV1 drives CD4 helper T cells
to the tumor to activate an immune system cascade and increase anti-tumor
responses. With a broad Phase II program in five cancer indications enrolling
more than 670 patients in Europe, the US and Australia, Ultimovacs aims to
clinically demonstrate UV1's impact in multiple cancer types, in combination
with other immunotherapies, for patients with unmet needs. Ultimovacs' second
technology approach, the proprietary Tetanus-Epitope-Targeting (TET) platform,
combines tumor-specific peptides and a tetanus-based adjuvant in the same
molecule.

For further information, please see www.ultimovacs.com or contact:

Carlos de Sousa, CEO
Email: carlos.desousa@ultimovacs.com (mailto:carlos.desousa@ultimovacs.com)
Phone: +47 908 92507

Anne Worsøe, Head of Investor Relations
Email: anne.worsoe@ultimovacs.com (mailto:anne.worsoe@ultimovacs.com)
Phone: +47 90686815

Mary-Ann Chang, LifeSci Advisors
Email: mchang@lifesciadvisors.com (mailto:mchang@lifesciadvisors.com)
Phone: +44 7483 284 853

This information is considered to be inside information pursuant to the EU
Market Abuse Regulation and is subject to the disclosure requirements pursuant
to Section 5-12 in the Norwegian Securities Trading Act.

This stock exchange announcement was published by Anne Worsøe, Head of Investor
Reat Ultimovacs ASA, on 13 April, 2023 at 11:30 CET.

More information:
Access the news on Oslo Bors NewsWeb site