Hofseth Biocare ASA: ProGo, the world's first consumer health GLP-1 & GIP receptor agonist with muscle mass protection via inhibition of Myostatin and Activin A pathways

09 Sep 2025 08:58 CEST

HBC has today released a whitepaper demonstrating how its bioactive peptide
ingredient ProGo® uniquely provides complete GLP-1 support.

To maximize the effect of GLP-1 therapy, lean muscle mass needs to be protected
to optimize the benefits of weight loss and support a healthy metabolism.

ProGo®? addresses these needs through its unique triple action properties:

* highly absorbable protein with a complete amino acid profile to help build
muscle
* antioxidant and anti-inflammatory bioactivity to protect muscle health
* inhibition of Activin A and Myostatin, negative regulators of muscle mass

ProGo®? is the only commercially available bioactive peptide health ingredient
that is both a GLP-1 RA (Receptor Agonist) and has a targeted mode of action for
muscle protection via inhibition of Myostatin & Activin A.

A fully traceable, high-quality nutritional supplement comprised of hydrolysed
peptides and collagen, it has a complete amino acid profile that includes high
levels of branched chain amino acids (BCAA) - essential for muscle formation and
health.

ProGo® also has a higher bioavailability than other peptides on the market, as
the smaller average size of peptides makes them easier for the body to digest.

For further information, please contact:

James Berger, CCO at Hofseth BioCare ASA
Phone: +41 79 950 1034
E-mail: jb@hofsethbiocare.no (mailto:jb@hofsethbiocare.no)

About Hofseth BioCare ASA:

HBC is a Norwegian consumer and pet health company founded on the core values of
sustainability, optimal utilization of natural resources and full traceability.
It upcycles the side streams of the salmon industry by taking fresh filleted
salmon and converting it from a waste product into ingredients to improve human
and pet health.

These ingredients are ProGo®, a mix of bioactive peptides and collagen, OmeGo®,
a whole salmon oil, with all the fatty acid fractions contained in fish, and
CalGo® / NT-II® salmon bone powder containing calcium hydroxyapatite and
undenatured collagen for bone and joint health.

HBC places scientific evidence at the forefront which has led to important
academic partnerships and the identification of unique health benefits. This
includes the demonstration of improved iron metabolism by boosting the body's
ability to take up and use iron resulting in increased energy and vitality with
ProGo® as well as the activation of the GLP-1 receptor with fat reduction in
overweight adults. OmeGo® has shown important immune health benefits including
recovery from viral infection and improved respiratory health and sleep in
adults troubled by particulate matter pollution. Finally, CalGo®/ NT-II® has
shown both bone and joint health benefits to support healthy ageing and active
lifestyles.

This work has also resulted in the granting of several patents protecting these
discoveries. It has also led to the discovery of potential therapeutics and HBC
has spun out a biotech-focused company, HBC Immunology (HBCI) has raised
external finance, and the lead program is in prostate cancer followed by ovarian
cancer. A separate molecule is targeted as an oral, steroid-sparing therapy for
asthma. HBC's headquarters are in Ålesund, Norway with branches in Oslo, London,
Zürich, Los Angeles, and Palo Alto.

HBC is listed on Oslo Stock Exchange with ticker "HBC".

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